"Nobody wanted to believe antibody-dependent enhancement. The only problem is it’s true. "
Q&A with Scott Halstead: Zika will subside in ‘5 years, max’
in Science Magazine, AAAS March 2016
"What might be the mechanism behind Zika virus harming fetuses? A: I think dengue antibody is complexing with Zika virus and the immune complex is infecting monocytes so you have a much higher amount of virus produced. Maybe above a certain concentration of virus you begin to get virus spilling over into placenta.
Q: When you proposed that antibodies against the four different strains of dengue could enhance the virus you weren’t immediately celebrated for the idea. A: Let me tell you something, it’s no fun to discover something that nobody wants to hear. I’ve always thought to myself I really discovered something pretty important, but actually it’s kind of horrible: People are making antibodies and killing themselves. Nobody wanted to believe antibody-dependent enhancement. The only problem is it’s true. "
"It absolutely would not surprise me to find that dengue antibodies enhance Zika infections and that this entire sweep of Zika across the Pacific and into South America has all been promoted and propelled by enhancement."