Zika Response
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The Zika Response Working Group

Observe. Analyze. Think. Take Action.

 

 
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Mission

The Zika Response Working Group, under the pending non-profit non-governmental organization iOrg (Infectious Outbreak Response Group), is rapidly responding to critical needs.  Our activities are focused on;

·        Threat and risk assessment and determination

·        Identifying existing licensed drugs likely to have anti-Zika activity

·        Modeling the outbreak to help inform government and corporate planning

·        Geo-spatial tracking and sequence analysis

·        Computational immunology and comparative proteome analysis including epitope mapping

·        Using surveys and alternative media to track the spread of Zika virus, Zika disease, Zika communication, and to identify the unmet needs of medical caregivers and their patients

·        Diagnostics and diagnostic technology research and development

·        Development, manufacturing and production of medical countermeasures for Zika disease (devices, drugs, biologicals, and vaccines)

·        Facilitating clinical trial design/clinical protocol development for rapid testing of preventative and therapeutic treatments

·        Expediting clinical development to licensure of diagnostics, devices, drugs, biotherapies and vaccines to prevent Zika Fetal syndrome and GBS

Our group is united by a commitment to enable rapid responses to the global human threat posed by Zika virus.  

We also believe that, while speed is essential when managing an emerging infectious disease outbreak, it is also important to first observe, analyze, think, discuss, and then to act.

 

Goals

Our group is united by a commitment to enable rapid responses to the global human threat posed by Zika virus.  

We also believe that, while speed is essential when managing an emerging infectious disease outbreak, it is also important to first observe, analyze, think, discuss, and then to act.

 
 
 

"WE NEED TO FIND AND DEVELOP DIAGNOSTICS, DEVICES, ANTI-VIRALS, VACCINES AND TO BUILD A BETTER UNDERSTANDING OF THE VIRUS AND THE EPIDEMIOLOGY OF THE VIRUS, SO THAT THE ZIKA VIRUS PROGRESSION AND DISEASE CAN BE REDUCED."

Jill G Malone, PHD  |  Co-Founder

 
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History

The Zika Response Group began in the winter of 2016.  News of Zika was rapidly spreading and the founders of iORG, Dr's Robert and Jill Malone wanted to do something to really make a difference.  Having worked in infectious disease outbreak response teams for many years, they realized that the usual governmental response was slow and inefficient.  The usual response time just was not a good solution to solve the spread of Zika and to develop a better understanding of the disease, so that treatments could be developed.  Robert spoke to many colleagues and the response was overwhelming.  together, they founded the Zika Response Group with iORG as the parent organization.  The was goal was simply to impact on the public health response to make it more efficient and to make a difference.  The team of people assembled worked night and day - and accomplished amazing things. 

Some of the early successes are:

  • Zika Response Working Group wrote a comprehensive meta analysis of Zika and available medical countermeasure options that has helped guide government officials, clinicians and front line public health workers as they are responding to the virus outbreak in January 2016.
  • Zika Response Working Group wrote an extensive review paper on Zika that has helped guide scientists about the virus.  Published in PLoS NTD.  The paper now has over 40,000 readers and is one of the most cited Zika references.
  • Members of the Zika Response Group have performed epitope mapping and computational biology analyses, showing the evolution of the virus - which will lead to a better vaccine and a better understanding of how the disease is causing damage to fetuses, as well as the mechanisms of action of GBS.  This effort culminated in two peer reviewed papers being published.  The Evolution of the Zika Virus paper, published in the fall of 2016, is one of Wiley's most read scientific articles, and is in the  99% of their top publications-  with 72,000 readers having already viewed the paper.
  • Members of our team have extensively consulted with USG and Brazilian government officials on how to control the pandemic.
  • Members of our team have consulting with the World Health Organization, and foreign public health officials on how to control the pandemic.
  • A member of the Zika Response Working Group is  working in South America on GBS. 
  • Members of our team have discovered possible anti-viral drugs that are safe for pregnant women and designed clinical trials, and are in the process of procuring funding and building partners in Latin America to move forward with clinical trials!
 
 
 

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